Affiliation:
1. Departments of Laboratory Medicine,1
2. Medicine,2 and
3. Epidemiology,3 University of Washington, Seattle, Washington
Abstract
SUMMARY
Prevention of genital herpes simplex virus (HSV) infections is desirable from both a public health standpoint and the patient’s perspective. A key factor in the spread of genital herpes infections is the high proportion of undiagnosed infections. Persons with subclinical or unrecognized infections are best diagnosed by accurate, type-specific antibody tests. Unfortunately, these tests are only now becoming widely available. The use of current, conventional (non-type-specific) serologic tests for diagnosis of herpes infections has resulted in confusion and misdiagnosis of patients. This review provides recent information on the epidemiology of genital herpes infections, describes the importance of subclinical herpes infection and shedding, summarizes the status of HSV type-specific serologic assays being developed, and provides indications for using such assays.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology
Reference84 articles.
1. Differential effect of systemic acyclovir treatment of genital HSV-2 infections on antibody responses to individual HSV-2 proteins.;Ashley R.;J. Med. Virol.,1988
2. Inability of enzyme immunoassays to discriminate between infections with herpes simplex virus types 1 or 2.;Ashley R.;Ann. Intern. Med.,1991
3. Laboratory techniques in the diagnosis of herpes simplex infection.;Ashley R.;Genitourin. Med.,1993
4. Ashley
R.
Warford
A.
Gleaves
C.
Zenilman
J.
Alexander
D.
Corey
L.
Evaluation of CHIRON RIBA HSV type-1/type-2 strip immunoblot assay for typing of HSV antibodies abstr. 29
Abstracts of the 35th Annual Meeting of the Infectious Disease Society of America 1997
1997
360
5. Type-specific antibodies to HSV-1 and -2: review of methodology.;Ashley R.;Herpes,1998
Cited by
149 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献