Affiliation:
1. Department of Medicine, Duke University Medical Center, and Veterans Administration Hospital, Durham, North Carolina 27705
Abstract
In 20 patients with acute pulmonary infections, sputum purulence, sputum volume, and concentration and excretion of cephalexin in the sputum significantly decreased concurrently during therapy. The concentration of cephalexin in the serum remained unchanged. Significant correlations were observed between drug concentrations in sputum and serum and between drug excretion in sputum and concentration in serum. These observations may be explained by decreased integrity of the “blood-bronchus barrier” during inflammation, with diffusion of serum into bronchial mucus, without the necessity of postulating active transport.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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