Affiliation:
1. Farmitalia, Milan, Italy
Abstract
Axenomycins are a new group of macrolide antibiotics isolated from the fermentation broth of
Streptomyces lisandri
n.sp. They exhibit anthelmintic activity against tapeworms (
Cestoda
). Three different fractions, A, B, and D, have been obtained, the most active fraction being axenomycin D. The activities of the axenomycin complex and axenomycin D against
Hymenolepis nana
in mice,
Taenia pisiformis, Dipylidium caninum
, and
Diphyllobothrium
sp. in dogs, and
Moniezia expansa, M. benedeni
, and
Avitellina centripunctata
in lambs were studied in experimentally and naturally infected animals. Axenomycins were effective and well tolerated by the oral route. Worm reduction rates after a single oral dose were 90 to 100% with 5 to 10 mg of axenomycin D/kg and 50 to 100% with 20 mg of axenomycin complex/kg.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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