Affiliation:
1. Kettering-Meyer Laboratories, Southern Research Institute, Birmingham, Alabama 35205
Abstract
1-Methyl-3-nitro-1-nitrosoguanidine was shown to have in vitro antimicrobial activity against fungi and gram-positive and gram-negative bacteria; it was also shown to have in vivo activity in mice experimentally infected with
Staphylococcus aureus
or
Escherichia coli
comparable to that observed with penicillin or streptomycin sulfate.
Publisher
American Society for Microbiology
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference8 articles.
1. Brown R. 1964. Experimental chemotherapy of systemic fungus infections p. 417-419. In R. J. Schnitzer and F. Hawking (ed.) Experimental chemotherapy vol. 3. Academic Press Inc. New York.
2. The physiological disposition of the carcinostatic 1,3-bis(2-chloroethyl)- 1-nitrosourea. (BCNU) in man and animals;De Vita D. T.;Clin. Pharmacol. Therap.,1967
3. Evaluation of antileukemic agents employing advanced leukemia L1210 in mice. IV. Cancer chemotherapy screening data;Goldin A.;Cancer Res. Suppl.,1959
4. Hunt D. E. and R. F. Pittillo. 1966. Antifungal action of 1 3-bis(2-chloroethyl)-1-nitrosourea. Antimicrobial Agents and Chemotherapy-1965 p. 710-716.
5. Filament formation and resistance to 1-methy1-3-nitro-lnitrosoguanidine and other radiomimetic compounds in Escherichia coli;Kilgore W. W.;J. Bacteriol.,1961