Expression of the aac(6′)-Ib-cr Gene in Class 1 Integrons-Reference-Cited by-同舟云学术

Expression of the aac(6′)-Ib-cr Gene in Class 1 Integrons

Published:2017-05 Issue:5 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Raherison Sophie¹²³,Jove Thomas¹²³,Gaschet Margaux¹²³,Pinault Emilie⁴,Tabesse Aurore¹²³,Torres Carmen⁵,Ploy Marie-Cécile¹²³

Affiliation:

1. University of Limoges, UMR_S1092, Limoges, France

2. INSERM, U1092, Limoges, France

3. CHU Limoges, Laboratoire de Bactériologie-Virologie-Hygiène, Limoges, France

4. University of Limoges SCRABL, Limoges, France

5. Biochemistry and Molecular Biology, University of La Rioja, Logroño, Spain

Abstract

ABSTRACT aac(6′)-Ib-cr is a plasmid-mediated quinolone resistance gene embedded within a gene cassette, most often within an integron. It confers resistance to quinolones and aminoglycosides. We investigated the role of a 101-bp fragment frequently present upstream of the aac(6′)-Ib-cr gene cassette and found that it contributes to the expression of aac(6′)-Ib-cr and provides an alternative start codon, confirming the length of the AAC(6′)-Ib-cr protein to 199 amino acids.

Funder

Institut National de la Santé et de la Recherche Médicale

Ministère de l'Enseignement Supérieur et de la Recherche Scientifique

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02704-16

Reference18 articles.

1. Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase

2. Quinolone resistance from a transferable plasmid