Pharmacological Targeting of Sphingosine Kinases Impedes HIV-1 Infection of CD4 T Cells through SAMHD1 Modulation-Reference-Cited by-同舟云学术

Pharmacological Targeting of Sphingosine Kinases Impedes HIV-1 Infection of CD4 T Cells through SAMHD1 Modulation

Published:2022-05-11 Issue:9 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Resop Rachel S.¹,Bosque Alberto¹^ORCID

Affiliation:

1. Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC, USA

Abstract

HIV-1 infection, once established, requires lifelong treatment due to the ability of the virus to maintain latent infection in its host and become reactivated during an interruption in antiretroviral treatment (ART). Although preventing transmission and acquisition of HIV is an important goal, no ART thus far have exploited harnessing a component of the host immune system to combat transmission of the virus.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00096-22

Reference36 articles.

1. HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure

2. Recovery of Replication-Competent HIV Despite Prolonged Suppression of Plasma Viremia

3. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

4. Generation of HIV latency during thymopoiesis

5. Molecular Characterization, Reactivation, and Depletion of Latent HIV

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Virus infection and sphingolipid metabolism;Antiviral Research;2024-08

2. Monkeypox Virus Crosstalk with HIV: An Integrated Skin Transcriptome and Machine Learning Study;ACS Omega;2023-11-29

3. Enzymatic independent role of sphingosine kinase 2 in regulating the expression of type I interferon during influenza A virus infection;PLOS Pathogens;2022-09-07

4. Schlafen family is a prognostic biomarker and corresponds with immune infiltration in gastric cancer;Frontiers in Immunology;2022-08-25