RNF123 Mediates Ubiquitination and Degradation of SOCS1 To Regulate Type I Interferon Production during Duck Tembusu Virus Infection

Author:

Huang Shanzhi12,Cui Min3,Huang Juan123,Wu Ziyu12,Cheng Anchun123ORCID,Wang Mingshu123,Zhu Dekang123ORCID,Chen Shun123,Liu Mafeng123ORCID,Zhao Xinxin123,Wu Ying123,Yang Qiao123,Zhang Shaqiu123,Ou Xumin123,Mao Sai123,Gao Qun123,Tian Bin123,Sun Di123,Yin Zhongqiong3,Jing Bo3,Jia Renyong123ORCID

Affiliation:

1. Research Centre of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, People’s Republic of China

2. Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, People’s Republic of China

3. Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, People’s Republic of China

Abstract

In recent years, posttranslational modification (PTM) has gradually become a research hot spot in the field of innate immunity regulation, and ubiquitination is one of the critical PTMs. DTMUV has seriously endangered the development of the waterfowl industry in Southeast Asian countries since its outbreak in 2009.

Funder

National Natural Science Foundation of China

MOA | Earmarked Fund for China Agriculture Research System

China's Agricultural Research System | Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System

Natural Science Foundation of Sichuan Province

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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