Interplay between Furin and Sialoglycans in Modulating Adeno-Associated Viral Cell Entry-Reference-Cited by-同舟云学术

Interplay between Furin and Sialoglycans in Modulating Adeno-Associated Viral Cell Entry

Published:2023-05-31 Issue:5 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Smith Timothy J.¹^ORCID,Fusco Robert M.²,Elmore Zachary C.³,Asokan Aravind¹²³^ORCID

Affiliation:

1. Department of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, North Carolina, USA

2. Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA

3. Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA

Abstract

Adeno-associated viruses (AAVs) are a proven recombinant vector platform for gene therapy and have demonstrated success in the clinic. Continuing to improve our knowledge of AAV-host cell interactions is critical for improving the safety and efficacy.

Funder

HHS | NIH | National Institute of General Medical Sciences

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00093-23

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2. Nucleotide sequence of the inverted terminal repetition in adeno-associated virus DNA

3. AAV Capsid Structure and Cell Interactions

4. Membrane-Associated Heparan Sulfate Proteoglycan Is a Receptor for Adeno-Associated Virus Type 2 Virions

5. Adeno-Associated Virus Serotype 4 (AAV4) and AAV5 Both Require Sialic Acid Binding for Hemagglutination and Efficient Transduction but Differ in Sialic Acid Linkage Specificity

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