Immunodiffusion Studies of Purified Equine Infectious Anemia Virus

Author:

Nakajima Hideo1,Ushimi Chuzo1

Affiliation:

1. Equine Infectious Anemia Research Division, National Institute of Animal Health, Kodaira, Tokyo, Japan

Abstract

Antigenicity of purified equine infectious anemia (EIA) virus was examined by immunodiffusion against sera obtained from horses experimentally infected with EIA virus. The purified virus reacted with the infected horse serum, and virus-specific precipitating antibody was demonstrated. Furthermore, it was found that purified EIA virus reacted against the serum of horses infected with all strains of EIA virus which were antigenically different from one another. From the result, group-specific components of the virus rather than strain-specific ones were considered to be involved in the reaction. Serological reactivity was lost by adding antiserum from the infected horse to the antigen. The precipitating antibody usually appeared in the serum 1 to 2 weeks after the first febrile attack of EIA and remained for a longer period. Some characteristics of the purified antigen and specificity of the reaction for EIA are described.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference15 articles.

1. Immunodiffusion reaction in equine infectious anemia;Coggins L.;Cornell Vet.,1970

2. Serial passages of equine infectious anemia virus in horse leukocyte culture;Kobayashi K.;Nat. Inst. Anim. Health Quart.,1967

3. Propagation and titration of equine infectious anemia virus in horse leukocyte culture;Kobayashi K.;Nat. Inst. Anim. Health Quart.,1967

4. Characteristics of complement fixing antigen of equine infectious anemia virus;Kono Y.;Nat. Inst. Anim. Health Quart.,1968

5. Viremia and immunological responses in horses infected with equine infectious anemia virus;Kono Y.;Nat. Inst. Anim. Health Quart.,1969

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