Chromosomal and Plasmid-Borne Tigecycline Resistance Genes tet (X3) and tet (X4) in Dairy Cows on a Chinese Farm-Reference-Cited by-同舟云学术

Chromosomal and Plasmid-Borne Tigecycline Resistance Genes tet (X3) and tet (X4) in Dairy Cows on a Chinese Farm

Published:2020-10-20 Issue:11 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Zhang Rong¹,Dong Ning²^ORCID,Zeng Yu¹,Shen Zhangqi³,Lu Jiayue¹,Liu Congcong¹,Huang Zhuo-an¹,Sun Qiaoling¹,Cheng Qipeng²⁴,Shu Lingbin¹,Cai Jiachang¹,Chan Edward Waichi⁴,Liu Dejun³,Chen Gongxiang¹,Wang Yang³,Chen Sheng²^ORCID

Affiliation:

1. Department of Clinical Laboratory, Second Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang, Hangzhou, China

2. Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong

3. Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China

4. State Key Lab of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, China

Abstract

We isolated 47 Acinetobacter strains carrying tet (X3) and 4 ST767 E. coli strains carrying tet (X4) from 296 rectal swab samples from dairy cows on a Chinese farm. tet (X3) was located on chromosomes or diverse plasmids, and tet (X4) was located on IncFIBκ/FIA(HI1)/X1 nontransferable plasmid. The coexistence of tet (X3) and carbapenemase genes, including bla OXA-58 and bla NDM-1 , was detected in 9 Acinetobacter spp.

Funder

Thirteen's Five-Year Plan of National Key Research and Development

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00674-20

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2. Emergence of mobile tigecycline resistance mechanism in Escherichia coli strains from migratory birds in China