Elucidation of the DNA-Binding Activity of VirF from Shigella flexneri for the <i>icsA</i> and <i>rnaG</i> Promoters and Characterization of the N-Terminal Domain To Identify Residues Crucial for Dimerization-Reference-Cited by-同舟云学术

Elucidation of the DNA-Binding Activity of VirF from Shigella flexneri for the icsA and rnaG Promoters and Characterization of the N-Terminal Domain To Identify Residues Crucial for Dimerization

Published:2023-04-25 Issue:4 Volume:205 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Dow Garrett T.¹,Young Anna M.¹,Garcia George A.¹

Affiliation:

1. Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, USA

Abstract

Antimicrobial-resistant (AMR) infections continue to rise dramatically, and the lack of new approved antibiotics is not ameliorating this crisis. A promising route to reduce AMR is by targeting virulence.

Funder

HHS | NIH | National Institute of General Medical Sciences

University of Michigan, Women in Science and Engineering Residence Program

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.00015-23

Reference54 articles.

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2. O’Neill J. 2014. Antimicrobial resistance: tackling a crisis for the health and wealth of nations. Review on Antimicrobial Resistance, London, United Kingdom.

3. Targeting virulence: a new paradigm for antimicrobial therapy

4. Morbidity and mortality due to shigella and enterotoxigenic Escherichia coli diarrhoea: the Global Burden of Disease Study 1990–2016

5. Antibiotic resistance threats in the United States, 2019

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1. Diffusible signal factors (DSFs) bind and repress VirF, the leading virulence activator of Shigella flexneri;Scientific Reports;2023-08-14

2. A Tale about Shigella: Evolution, Plasmid, and Virulence;Microorganisms;2023-06-30