Affiliation:
1. Department of Medicine, the Medical College of Pennsylvania, Philadelphia, Pennsylvania 19129
Abstract
Nafcillin, methicillin, and cephalothin (40 mg/kg every 6 h) were all effective in reducing the number of
Staphylococcus aureus
in vegetations in rabbits with endocarditis. Nafcillin and methicillin reduced the number of
S. aureus
at a significantly faster rate than did cephalothin. Nafcillin and methicillin also reduced titers of the
S. aureus
more rapidly than did cephalothin in vitro, both in broth and in rabbit serum.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
25 articles.
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