Protective Role of Lung Surfactant Protein D in a Murine Model of Invasive Pulmonary Aspergillosis

Author:

Madan Taruna1,Kishore Uday23,Singh Mamta14,Strong Peter2,Hussain Ejaj M.4,Reid Kenneth B. M.2,Sarma P. Usha1

Affiliation:

1. Centre for Biochemical Technology, Council for Scientific and Industrial Research, Delhi 110007,1 and

2. Department of Biochemistry, Medical Research Council Immunochemistry Unit, University of Oxford, Oxford OX1 3QU,2 and

3. Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS,3 United Kingdom

4. Department of Biosciences, Jamia Millia Central University, Delhi 110025,4India, and

Abstract

ABSTRACT The protective effects of intranasal administration of amphotericin B (AmB), human SP-A, SP-D and a 60-kDa fragment of SP-D (rSP-D) were examined in a murine model of invasive pulmonary aspergillosis (IPA). The untreated group of IPA mice showed no survival at 7 days postinfection. Treatment with AmB, SP-D, and rSP-D increased the survival rate to 80, 60, and 80%, respectively, suggesting that SP-D (and rSP-D) can protect immunosuppressed mice from an otherwise fatal challenge with Aspergillus fumigatus conidia.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference30 articles.

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3. The clinical spectrum of aspergillosis. II. Classification and description of saprophyte, allergic, and invasive variants of human disease;Bardana E.;Crit. Rev. Clin. Lab. Sci.,1981

4. Aspergillosis;Bodey G. P.;Eur. J. Clin. Microbiol. Infect. Dis.,1989

5. Recombinant SP-D carbohydrate recognition domain is a chemoattractant for human neutrophils;Cai G.-J.;Am. J. Physiol.,1999

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