Evidence of Involvement of the Mannose Receptor in Adhesion of Borrelia burgdorferi to Monocyte/Macrophages-Reference-Cited by-同舟云学术

Evidence of Involvement of the Mannose Receptor in Adhesion of Borrelia burgdorferi to Monocyte/Macrophages

Published:2001-04 Issue:4 Volume:69 Page:2743-2747
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Cinco Marina¹,Cini Barbara¹,Murgia Rossella¹,Presani Gianni²,Prodan Mario²,Perticarari Sandra²

Affiliation:

1. Dipartimento di Scienze Biomediche, Università di Trieste,1 and

2. Laboratorio di Analisi Cliniche, IRCCS, “Burlo Garofolo,”2 Trieste, Italy

Abstract

ABSTRACT The mannose receptor (MR) plays an important role in the recognition of some pathogens in nonopsonic phagocytosis and in antigen presentation to T cells. We found that Borrelia burgdorferi , the agent of Lyme borreliosis, adheres to monocyte-derived macrophages and to rat MR-transfected cells but not to untransfected cells. Antibodies to MR and sugars such as mannose, mannan, fucose, and some lectins significantly lowered the adhesion, confirming participation of the MR in the binding.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.69.4.2743-2747.2001

Reference27 articles.

1. The lipid component of lipoproteins from Borrelia burgdorferi: structural analysis, antigenicity and presentation via human dendritic cells;Beerman C.;Biochem. Biophys. Res. Commun.,2000

2. Lipoproteins from Borrelia burgdorferi applied in liposomes and presented by dendritic cells induce CD8+ T-lymphocytes in vitro;Beermann C.;Cell. Immunol.,2000

3. Simultaneous measurement by flow cytometry of phagocytosis and metabolic burst induced in phagocytic cells in whole blood by Borrelia burgdorferi;Cinco M.;FEMS Microbiol. Lett.,1994

4. Integrin CR3 mediates the binding of nonspecifically opsonized Borrelia burgdorferi to human phagocytes and mammalian cells

5. Surface receptors of neutrophils towards B. burgdorferi;Cinco M.;Middle Eur. J. Med.,1998

Cited by 26 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A joint effort: The interplay between the innate and the adaptive immune system in Lyme arthritis;Immunological Reviews;2020-01-13

2. A bite so sweet: the glycobiology interface of tick-host-pathogen interactions;Parasites & Vectors;2018-11-14

3. Phagocytic Receptors Activate Syk and Src Signaling during Borrelia burgdorferi Phagocytosis;Infection and Immunity;2017-10

4. Borrelia- induced cytokine production is mediated by spleen tyrosine kinase (Syk) but is Dectin-1 and Dectin-2 independent;Cytokine;2015-12

5. Innate immunity networks during infection withBorrelia burgdorferi;Critical Reviews in Microbiology;2014-06-25