Saccharomyces boulardii Stimulates Intestinal Immunoglobulin A Immune Response to Clostridium difficile Toxin A in Mice-Reference-Cited by-同舟云学术

Saccharomyces boulardii Stimulates Intestinal Immunoglobulin A Immune Response to Clostridium difficile Toxin A in Mice

Published:2001-04 Issue:4 Volume:69 Page:2762-2765
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Qamar Amir¹,Aboudola Samer¹,Warny Michel¹,Michetti Pierre¹,Pothoulakis Charalabos¹,LaMont J. Thomas¹,Kelly Ciarán P.¹

Affiliation:

1. Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215

Abstract

ABSTRACT Saccharomyces boulardii is a nonpathogenic yeast that protects against antibiotic-associated diarrhea and recurrent Clostridium difficile colitis. The administration of C. difficile toxoid A by gavage to S. boulardii -fed BALB/c mice caused a 1.8-fold increase in total small intestinal immunoglobulin A levels ( P = 0.003) and a 4.4-fold increase in specific intestinal anti-toxin A levels ( P < 0.001). Enhancing host intestinal immune responses may be an important mechanism for S. boulardii -mediated protection against diarrheal illnesses.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.69.4.2762-2765.2001

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