Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones-Reference-Cited by-同舟云学术

Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones

Published:2003-04 Issue:4 Volume:47 Page:1449-1451
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lunardi Fabiane¹²,Guzela Michel¹,Rodrigues Andrea T.¹,Corrêa Rogério¹,Eger-Mangrich Iriane¹²,Steindel Mário²,Grisard Edmundo C.²,Assreuy Jamil³,Calixto João B.³,Santos Adair R. S.⁴

Affiliation:

1. Faculdade de Farmácia, Centro de Ciências da Saúde, Universidade do Vale do Itajaí

2. Departamento de Microbiologia e Parasitologia

3. Departamento de Farmacologia

4. Departamento de Ciências Fisiológicas, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil

Abstract

ABSTRACT Ten chalcones were synthesized and tested as potential leishmanicidal and trypanocidal agents. All tested compounds caused concentration-dependent inhibition of the in vitro growth of Leishmania braziliensis and Trypanosoma cruzi with no significant toxic effect towards host macrophages. Our results show that the positions of the substituents seem to be critical for their antiprotozoal activities.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.4.1449-1451.2003

Reference20 articles.

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