Five Homologous Repeats of the Protein G-Related Protein MIG Cooperate in Binding to Goat Immunoglobulin G-Reference-Cited by-同舟云学术

Five Homologous Repeats of the Protein G-Related Protein MIG Cooperate in Binding to Goat Immunoglobulin G

Published:1999-01 Issue:1 Volume:67 Page:413-416
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Vasi József¹,Svensson Jan¹,Frick Inga-Maria²,Müller Hans-Peter¹³

Affiliation:

1. Department of Microbiology, SLU, Uppsala,1 and

2. Department of Cell and Molecular Biology, Section for Molecular Pathogenesis, Lund University, Lund,2 Sweden and

3. Department of Immunology and Transfusion Medicine, University of Greifswald, Greifswald, Germany3

Abstract

ABSTRACT Protein MIG, from Streptococcus dysgalactiae , binds α 2 -macroglobulin and immunoglobulin G (IgG). MIG-derived fusion proteins with one to five IgG-binding repeats differed up to 72,000-fold in avidity for goat IgG, indicating a considerable cooperativity of the repeats. Significant sequence variation in the IgG-binding repeats was recognized. Protein MIG interacted with goat IgG1 via both the Fc and Fab parts.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.67.1.413-416.1999

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