Salmonella typhimurium IroN and FepA Proteins Mediate Uptake of Enterobactin but Differ in Their Specificity for Other Siderophores

Author:

Rabsch Wolfgang1,Voigt Wolfgang1,Reissbrodt Rolf1,Tsolis Renée M.2,Bäumler Andreas J.3

Affiliation:

1. National Reference Center for Salmonellae and Other Enterics, Robert Koch-Institute, D-38855 Wernigerode, Germany1;

2. Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843-44672; and

3. Department of Medical Microbiology and Immunology, College of Medicine, Texas A&M University Health Science Center, College Station, Texas 77843-11143

Abstract

ABSTRACT Salmonella typhimurium possesses two outer membrane receptor proteins, IroN and FepA, which have been implicated in the uptake of enterobactin. To determine whether both receptors have identical substrate specificities, fepA and iroN mutants and a double mutant were characterized. While both receptors transported enterobactin, the uptake of corynebactin and myxochelin C was selectively mediated by IroN and FepA, respectively.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference23 articles.

1. Myxochelins B, C, D, E and F: a new structural principle for powerful siderophores imitating nature;Ambrosi H. D.;Eur. J. Org. Chem.,1998

2. Molecular analysis of the Escherichia coli ferric enterobactin receptor FepA;Armstrong S. K.;J. Biol. Chem.,1980

3. IroN, a Novel Outer Membrane Siderophore Receptor Characteristic of Salmonella enterica

4. Braun V. Hantke K. Genetics of bacterial iron transport Handbook of microbial iron chelates. Winkelmann G. 1991 107 138 CRC Press Boca Raton Fla

5. Corynebactin, a cyclic catecholate siderophore from Corynebacterium glutamicum ATCC14067 (Brevibacterium sp. DSM 20411);Budzikiewicz H.;Z. Naturforsch. Sect. C,1997

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