Affiliation:
1. Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin 53706
Abstract
ABSTRACT
In the present study, we demonstrate that the yeast form of
Blastomyces dermatitidis
can proliferate for short periods of time in the absence of ferric iron but not in the absence of calcium or magnesium. The results of this study shed light on the resistance of
B. dermatitidis
to chelating agents, such as deferoxamine, and may explain how
B. dermatitidis
resists the iron-binding activity of serum transferrin.
Publisher
American Society for Microbiology
Subject
Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy
Reference25 articles.
1. Bloom, J. D., R. E. Hamor, and P. A. Gerding. 1996. Ocular blastomycosis in dogs—73 cases, 108 eyes (1985-1993). J. Am. Vet. Med. Assoc.209:1271-1274.
2. Boelaert, J., M. de Locht, J. Van Cutsem, V. Kerrels, B. Cantinieaux, A. Verdonck, H. Van Landuyt, and Y. Schneider. 1993. Mucormycosis during deferoxamine therapy is a siderophore-mediated infection. In vitro and in vivo animal studies. J. Clin. Investig.91:1979-1986.
3. Bradsher, R., W. Ulmer, D. Marmer, J. Townsend, and R. Jacobs. 1985. Intracellular growth and phagocytosis of Blastomyces dermatitidis by monocyte-derived macrophages from previously infected and normal subjects. J. Infect. Dis.151:57-64.
4. Buyukmihci, N. 1982. Ocular lesions of blastomycosis in the dog. J. Am. Vet. Med. Assoc.180:426-431.
5. Action of Deferoxamine against
Pneumocystis carinii
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