Molecular Mechanism of N , N -Dimethylformamide Degradation in Methylobacterium sp. Strain DM1-Reference-Cited by-同舟云学术

Molecular Mechanism of N , N -Dimethylformamide Degradation in Methylobacterium sp. Strain DM1

Published:2019-06-15 Issue:12 Volume:85 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Lu Xinyu¹,Wang Weiwei¹,Zhang Lige¹,Hu Haiyang¹,Xu Ping¹,Wei Tao²,Tang Hongzhi¹

Affiliation:

1. State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People’s Republic of China

2. School of Food and Biological Engineering, Zhengzhou University of Light Industry, Henan, People’s Republic of China

Abstract

DMF is a hazardous pollutant that has been used in the chemical industry, pharmaceutical manufacturing, and agriculture. Biodegradation as a method for removing DMF has received increasing attention. Here, we identified an efficient DMF degrader, Methylobacterium sp. strain DM1, and characterized the complete DMF mineralization pathway and enzymatic properties of DMFase in this strain. This study provides insights into the molecular mechanisms and evolutionary advantage of DMF degradation facilitated by plasmid pLVM1 and redundant genes in strain DM1, suggesting the emergence of new ecotypes of Methylobacterium .

Funder

Henan Province Foreign Cooperation Projects

Chinese National Science Foundation for Excellent Young Scholars

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Shanghai Education Development Foundation

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.00275-19