Gammaherpesvirus RNAs Come Full Circle

Author:

Ungerleider Nathan A.1,Tibbetts Scott A.2,Renne Rolf2,Flemington Erik K.1

Affiliation:

1. Department of Pathology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, Louisiana, USA

2. Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, USA

Abstract

After an adaptive immune response is mounted, gammaherpesviruses achieve persistence through the utilization of viral noncoding RNAs to craft a suitable host cell environment in an immunologically transparent manner. While gammaherpesvirus long noncoding RNAs (lncRNAs) and microRNAs have been recognized for some time and have been actively investigated, a recent spate of reports have now identified repertoires of the circular RNA (circRNA) class of noncoding RNAs in both the lymphocryptovirus and rhadinovirus genera of gammaherpesviruses.

Funder

HHS | National Institutes of Health

U.S. Department of Defense

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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