Affiliation:
1. Department of Immunology, Microbiology, Pathology and Infectious Diseases and Department of Oral and Maxillofacial Surgery, Karolinska Institutet, Huddinge University Hospital, F82, S-141 86 Huddinge, Sweden
Abstract
ABSTRACT
A novel mechanism for enhancement of adherence of
Staphylococcus aureus
to host components is described. A secreted protein, Eap (extracellular adherence protein), was purified from the supernatant of
S. aureus
Newman and found to be able to bind to at least seven plasma proteins, e.g., fibronectin, the α-chain of fibrinogen, and prothrombin, and to the surface of
S. aureus
. Eap bound much less to cells of
Staphylococcus epidermidis
,
Streptococcus mutans
, or
Escherichia coli
. The protein can form oligomeric forms and is able to cause agglutination of
S. aureus
. Binding of
S. aureus
to fibroblasts and epithelial cells was significantly enhanced by addition of Eap, presumably due to its affinity both for plasma proteins on the cells and for the bacteria.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
124 articles.
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