Simplified Aztreonam Dosing in Patients with End-Stage Renal Disease: Results of a Monte Carlo Simulation-Reference-Cited by-同舟云学术

Simplified Aztreonam Dosing in Patients with End-Stage Renal Disease: Results of a Monte Carlo Simulation

Published:2018-11 Issue:11 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Gross Alan E.¹²,Xu Hongmei³,Zhou Diansong³,Al-Huniti Nidal³

Affiliation:

1. University of Illinois at Chicago College of Pharmacy, Department of Pharmacy Practice, Chicago, Illinois, USA

2. University of Illinois Hospital and Health Sciences System, Hospital Pharmacy Services, Chicago, Illinois, USA

3. Quantitative Clinical Pharmacology, Early Clinical Development, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA

Abstract

The manufacturer-recommended aztreonam dosing for patients with creatinine clearance values of <10 ml/min/1.73 m 2 is complex. It is not known whether simpler posthemodialysis dosing administered once daily or thrice weekly can reliably achieve pharmacodynamic goals.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01066-18

Reference21 articles.

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2. Can Ceftazidime-Avibactam and Aztreonam Overcome β-Lactam Resistance Conferred by Metallo-β-Lactamases in Enterobacteriaceae?

3. Background and Rationale for Revised Clinical and Laboratory Standards Institute Interpretive Criteria (Breakpoints) for Enterobacteriaceae andPseudomonas aeruginosa:I. Cephalosporins and Aztreonam

4. Clinical and Laboratory Standards Institute. 2018. Performance standards for antimicrobial susceptibility testing, 28th ed. M100. Clinical and Laboratory Standards Institute, Wayne, PA.

5. Ramsey CBK Noel AR Attwood MLG Tomaselli ST MacGowan AP. 2015. Pharmacodynamics of aztreonam against E. coli studied in an in vitro model of infection. Abstr 55th Intersci Conf Antimicrob Agents Chemother abstr A471.

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