No Evidence of Plasmodium falciparum k13 Artemisinin Resistance-Conferring Mutations over a 24-Year Analysis in Coastal Kenya but a Near Complete Reversion to Chloroquine-Sensitive Parasites-Reference-Cited by-同舟云学术

No Evidence of Plasmodium falciparum k13 Artemisinin Resistance-Conferring Mutations over a 24-Year Analysis in Coastal Kenya but a Near Complete Reversion to Chloroquine-Sensitive Parasites

Published:2019-12 Issue:12 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wamae Kevin¹^ORCID,Okanda Dorcas²,Ndwiga Leonard¹,Osoti Victor¹,Kimenyi Kelvin M.¹²,Abdi Abdirahman I.¹³,Bejon Philip¹⁴,Sutherland Colin⁵⁶,Ochola-Oyier Lynette Isabella¹³

Affiliation:

1. KEMRI-Wellcome Trust Research Programme, CGMRC, Kilifi, Kenya

2. Centre for Biotechnology and Bioinformatics, University of Nairobi, Nairobi, Kenya

3. Pwani University Bioscience Research Centre, Pwani University, Kilifi, Kenya

4. Nuffield Department of Medicine, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom

5. Department of Immunology and Infection, Faculty of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

6. PHE Malaria Reference Laboratory, London School of Hygiene and Tropical Medicine, London, United Kingdom

Abstract

Antimalarial drug resistance is a substantial impediment to malaria control. The spread of resistance has been described using genetic markers, which are important epidemiological tools. We carried out a temporal analysis of changes in allele frequencies of 12 drug resistance markers over 2 decades of changing antimalarial drug policy in Kenya.

Funder

DELTAS Africa Initiative

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01067-19

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1. Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum

2. Intercontinental Spread of Pyrimethamine-Resistant Malaria