In Vivo Pharmacodynamic Characterization of a Novel Odilorhabdin Antibiotic, NOSO-502, against Escherichia coli and Klebsiella pneumoniae in a Murine Thigh Infection Model-Reference-Cited by-同舟云学术

In Vivo Pharmacodynamic Characterization of a Novel Odilorhabdin Antibiotic, NOSO-502, against Escherichia coli and Klebsiella pneumoniae in a Murine Thigh Infection Model

Published:2018-09 Issue:9 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Zhao Miao¹²,Lepak Alexander J.¹,Marchillo Karen²,VanHecker Jamie²,Andes David R.¹³²

Affiliation:

1. Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

2. William S. Middleton Memorial VA Hospital, Madison, Wisconsin, USA

3. Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin, USA

Abstract

NOSO-502 is a novel odilorhabdin antibiotic with potent activity against Enterobacteriaceae . The goal of these studies was to determine which pharmacokinetic/pharmacodynamic (PK/PD) indices and magnitude best correlated with efficacy in the murine thigh infection model.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01067-18

Reference18 articles.

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