Efficacy of Three Antiretroviral Regimens Initiated during Pregnancy: Clinical Experience in Rio de Janeiro-Reference-Cited by-同舟云学术

Efficacy of Three Antiretroviral Regimens Initiated during Pregnancy: Clinical Experience in Rio de Janeiro

Published:2020-11-17 Issue:12 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Benamor Teixeira Maria de Lourdes¹²,Fuller Trevon L.¹,Fragoso Da Silveira Gouvêa Maria Isabel¹²,Santos Cruz Maria Letícia¹,Ceci Loredana¹,Pinheiro Lattanzi Fellipe¹,Sidi Leon Claude¹,Mendes-Silva Wallace³,Nielsen-Saines Karin⁴,Joao Esau Custodio¹^ORCID

Affiliation:

1. Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil

2. Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil

3. Maternity-Fetal Department and Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil

4. Department of Pediatric Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, California, USA

Abstract

Few studies have compared the clinical efficacy and adverse events of combined antiretroviral therapy (cART) regimens in pregnant women seeking obstetrical care. The objective of this study was to compare the efficacy (virus load response), adverse events, and obstetrical and neonatal outcomes of three different regimens of cART in HIV-infected pregnant women initiating treatment in Rio de Janeiro, Brazil. This was a retrospective cohort study of cART-naive pregnant women who initiated either ritonavir-boosted protease inhibitors (atazanavir or lopinavir), efavirenz, or raltegravir plus a backbone regimen.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01068-20

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