Intracellular Activity of Antibiotics against Coxiella burnetii in a Model of Activated Human THP-1 Cells-Reference-Cited by-同舟云学术

Intracellular Activity of Antibiotics against Coxiella burnetii in a Model of Activated Human THP-1 Cells

Published:2021-11-17 Issue:12 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Peyrusson Frédéric¹,Whelan Adam O.²,Hartley Margaret G.²,Norville Isobel H.²,Harding Sarah V.²,Van Bambeke Françoise¹^ORCID

Affiliation:

1. Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium

2. Defence Science and Technology Laboratory, Salisbury, United Kingdom

Abstract

We evaluated antibiotic activity against the intracellular bacterium Coxiella burnetii using an activated THP-1 cell model of infection. At clinically relevant concentrations, the intracellular bacterial load was reduced 300-fold by levofloxacin and finafloxacin, 40-fold by doxycycline, and 4-fold by ciprofloxacin and was unaffected by azithromycin.

Funder

Belgian Fonds de la Recheche Scientifique

Defense Science and Technology Laboratory

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01061-21

Reference18 articles.

1. From Q Fever to Coxiella burnetii Infection: a Paradigm Change

2. Comparative virulence of intra- and interstrain lipopolysaccharide variants of Coxiella burnetii in the guinea pig model