Affiliation:
1. Division of Medical Chemistry, Walter Reed Army Institute of Research, Washington, D.C. 20012
2. University of Miami School of Medicine, Medical Research Annex, Miami, Florida 33142
Abstract
Of 49 compounds known to have antitumor properties, 6 were found to have significant activity against
Trypanosoma rhodesiense
infections in mice. Activity against the African trypanosomes has not been reported previously for any of these six compounds. In order of decreasing activity these compounds were: (i) imidazole-4-carboxamide, 5-(3,3-dimethyl-1,1-triazene), (ii) inosine diglycolaldehyde, (iii)
cis
-diamminedichloro-platinum, (iv) streptozotocin, (v) coralyne sulfate, and (vi) 5-fluoro-2′-deoxyuridine. The percentage of “hits” (12.2%) from these known antitumor agents was approximately twice as great as when other means are employed for the selection of compounds for this test system.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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