Determination of Immunoglobulin A against Gardnerella vaginalis Hemolysin, Sialidase, and Prolidase Activities in Vaginal Fluid: Implications for Adverse Pregnancy Outcomes-Reference-Cited by-同舟云学术

Determination of Immunoglobulin A against Gardnerella vaginalis Hemolysin, Sialidase, and Prolidase Activities in Vaginal Fluid: Implications for Adverse Pregnancy Outcomes

Published:2003-01 Issue:1 Volume:41 Page:435-438
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Cauci Sabina¹,Thorsen Poul²,Schendel Diana E.³,Bremmelgaard Annie⁴,Quadrifoglio Franco¹,Guaschino Secondo⁵

Affiliation:

1. Department of Biomedical Sciences and Technologies, School of Medicine, University of Udine, Udine

2. Department of Epidemiology and Social Medicine and Danish Epidemiology Science Centre, Aarhus University, Aarhus

3. National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia

4. Department of Clinical Microbiology, Frederiksberg Hospital, Copenhagen, Denmark

5. Obstetric and Gynecologic Unit, Department of Reproductive and Development Sciences, IRCCS Burlo Garofolo Hospital, University of Trieste, Trieste, Italy

Abstract

ABSTRACT A nested case-control study of low birth weight and preterm delivery was performed with singleton women. Immunoglobulin A (IgA) against the Gardnerella vaginalis hemolysin (anti-Gvh IgA) and sialidase and prolidase activities were determined in vaginal fluid at 17 weeks of gestation. Sialidase positivity and bacterial vaginosis with high prolidase activity were associated with 2- and 11-fold increased risks for low birth weight, respectively. No woman with bacterial vaginosis plus a strong anti-Gvh IgA response had an adverse outcome.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.41.1.435-438.2003

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