Expanding U.S. Laboratory Capacity for Neisseria gonorrhoeae Antimicrobial Susceptibility Testing and Whole-Genome Sequencing through the CDC's Antibiotic Resistance Laboratory Network

Author:

Kersh Ellen N.1ORCID,Pham Cau D.1,Papp John R.1,Myers Robert2,Steece Richard3,Kubin Grace4,Gautom Romesh5,Nash Evelyn E.1,Sharpe Samera1,Gernert Kim M.1,Schmerer Matthew1,Raphael Brian H.1,Henning Tara6,Gaynor Anne M.7,Soge Olusegun8ORCID,Schlanger Karen1,Kirkcaldy Robert D.1,St. Cyr Sancta B.1,Torrone Elizabeth A.1,Bernstein Kyle1,Weinstock Hillard1

Affiliation:

1. Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

2. Maryland Department of Health Laboratories Administration, Baltimore, Maryland, USA

3. Tennessee Department of Health, Division of Laboratory Services, Nashville, Tennessee, USA

4. Texas Department of State Health Service, Austin, Texas, USA

5. Washington State Public Health Laboratories, Shoreline, Washington, USA

6. Antibiotic Resistance Coordination and Strategy (ARX) Unit, Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

7. Association of Public Health Laboratories, Silver Spring, Maryland, USA

8. University of Washington, Seattle, Washington, USA

Abstract

U.S. gonorrhea rates are rising, and antibiotic-resistant Neisseria gonorrhoeae (AR-Ng) is an urgent public health threat. Since implementation of nucleic acid amplification tests for N. gonorrhoeae identification, the capacity for culturing N. gonorrhoeae in the United States has declined, along with the ability to perform culture-based antimicrobial susceptibility testing (AST). Yet AST is critical for detecting and monitoring AR-Ng.

Funder

HHS | Centers for Disease Control and Prevention

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference29 articles.

1. CDC. 2019. Sexually transmitted disease surveillance 2018. https://www.cdc.gov/std/stats18/default.htm.

2. Antimicrobial Resistance in Neisseria gonorrhoeae in the 21st Century: Past, Evolution, and Future

3. Centers for Disease Control and Prevention Sexually Transmitted Diseases Treatment Guidelines

4. CDC. 2013. Antibiotic resistance threats in the United States 2013. https://www.cdc.gov/drugresistance/threat-report-2013/pdf/ar-threats-2013-508.pdf.

5. Recommendations for the laboratory-based detection of Chlamydia trachomatis and Neisseria gonorrhoeae—2014;Centers for Disease Control and Prevention;MMWR Recomm Rep,2014

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