Genomic Serotyping, Clinical Manifestations, and Antimicrobial Resistance of Nontyphoidal Salmonella Gastroenteritis in Hospitalized Children in Ho Chi Minh City, Vietnam

Author:

Duong Vu Thuy12,The Hao Chung1,Nhu Tran Do Hoang1,Tuyen Ha Thanh1,Campbell James I.1,Minh Pham Van1,Phuc Hoang Le2,Chau Tran Thi Hong1,Ngoc Nguyen Minh3,Vi Lu Lan4,Mather Alison E.56,Baker Stephen7ORCID

Affiliation:

1. The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam

2. Children’s Hospital No. 1, Ho Chi Minh City, Vietnam

3. Children’s Hospital No. 2, Ho Chi Minh City, Vietnam

4. The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

5. Quadram Institute Bioscience, Norwich, United Kingdom

6. University of East Anglia, Norwich, United Kingdom

7. Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge, Cambridge, United Kingdom

Abstract

Nontyphoidal Salmonella (NTS) are among the most common etiological agents of diarrheal diseases worldwide and have become the most commonly detected bacterial pathogen in children hospitalized with diarrhea in Vietnam. Aiming to better understand the epidemiology, serovar distribution, antimicrobial resistance (AMR), and clinical manifestation of NTS gastroenteritis in Vietnam, we conducted a clinical genomics investigation of NTS isolated from diarrheal children admitted to one of three tertiary hospitals in Ho Chi Minh City.

Funder

Wellcome Trust

UKRI | Biotechnology and Biological Sciences Research Council

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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