Affiliation:
1. Department of Protozoology, Oswaldo Cruz Institute-FIOCRUZ, Rio de Janeiro, Brazil.
Abstract
Fourteen patients suffering from American cutaneous leishmaniasis were studied. Assays of the lymphocyte proliferative response induced in vitro by Leishmania braziliensis antigens were performed. After 5 days in culture, L. braziliensis-stimulated blast T cells were harvested for CD4+ and CD8+ phenotype analysis. When results before and at the end of therapy were compared, leishmaniasis patients showed an increase in the percentage of CD8+ blast T cells and a decline in the proportion of CD4+ blast T cells in cultures. The levels of gamma interferon in T-cell culture supernatants showed a tendency to increase when the patients were cured. These results show a pattern of higher proportions of Leishmania-reactive CD8+ T cells and lower proportions of Leishmania-reactive CD4+ T cells after cure.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference40 articles.
1. Controlled field trial of a vaccine against New World cutaneous leishmaniasis;Antunes C. M. F.;Int. J. Epidemiol.,1986
2. Administration of monoclonal anti-IFN--y antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major;Belosevic M.;J. Immunol.,1989
3. Establishment of stable cell-mediated immunity that makes "susceptible;Bretscher P. A.;Science,1992
4. Cell mediated immunity in American cutaneous and mucosal leishmaniasis;Carvalho E. M.;J. Immunol.,1985
5. T-cell subpopulations, expression of interleukin-2 receptor, and production of interleukin-2 and gamma interferon in human American cutaneous leishmaniasis;Castes M.;J. Clin. Microbiol.,1988
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