Case Report and Molecular Analysis of Subacute Sclerosing Panencephalitis in a South African Child

Author:

Vardas Eftyhia1,Leary P. M.2,Yeats Jane3,Badrodien Waseila2,Kreis Stephanie1

Affiliation:

1. National Institute for Virology and Department of Virology, University of the Witwatersrand, Johannesburg,1 and

2. Red Cross Children’s Hospital, Department of Paediatrics,2 and

3. Department of Medical Virology,3University of Cape Town, Cape Town, South Africa

Abstract

ABSTRACT This is the first case of subacute sclerosing panencephalitis from South Africa in which the molecular characteristics of the causative measles virus were examined. The virus found is classified as genotype D3, which has not previously been found in Africa and was last circulating in the United States before 1992.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference15 articles.

1. Clonal expansion of hypermutated measles virus in SSPE brain;Baczko K.;Virology,1993

2. Genetic diversity of wild-type measles viruses: implications for global measles elimination programmes;Bellini W. J.;Emerg. Infect. Dis.,1998

3. Subacute sclerosing panencephalitis in South Africa;Carman W. F.;Trans. R. Soc. Trop. Med. Hyg.,1989

4. Register of cases of subacute sclerosing panencephalitis (SSPE) in Southern Africa;Kipps A.;S. Afr. Med. J.,1977

5. Sequence analysis of the nucleocapsid gene of measles virus isolates from South Africa identifies a new genotype;Kreis S.;J. Gen. Virol.,1997

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