Author:
Liu Chang,Tang Jian,Ma Yuanmei,Liang Xueya,Yang Yang,Peng Guiqing,Qi Qianqian,Jiang Shibo,Li Jianrong,Du Lanying,Li Fang
Abstract
Porcine epidemic diarrhea coronavirus (PEDV) has significantly damaged America's pork industry. Here we investigate the receptor usage and cell entry of PEDV. PEDV recognizes protein receptor aminopeptidase N from pig and human and sugar coreceptorN-acetylneuraminic acid. Moreover, PEDV infects cells from pig, human, monkey, and bat. These results support the idea of bats as an evolutionary origin for PEDV, implicate PEDV as a potential threat to other species, and suggest antiviral strategies to control its spread.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
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