Inducible Mega-Mediated Macrolide Resistance Confers Heteroresistance in Streptococcus pneumoniae

Author:

Lohsen Sarah1ORCID,Stephens David S.12ORCID

Affiliation:

1. Departments of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA

2. Departments of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA

Abstract

In Streptococcus pneumoniae ( Spn ), the 5.4 to 5.5 kb Macrolide Genetic Assembly (Mega) encodes an efflux pump (Mef[E]) and a ribosomal protection protein (Mel) conferring antibiotic resistance to commonly used macrolides in clinical isolates. We found the macrolide-inducible Mega operon provides heteroresistance (more than 8-fold range in MICs) to 14- and 15-membered ring macrolides.

Funder

Emory University Stephen W. Schwartzmann endowment

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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