Mycobacterium tuberculosis Arylamine N -Acetyltransferase Acetylates and Thus Inactivates para -Aminosalicylic Acid-Reference-Cited by-同舟云学术

Mycobacterium tuberculosis Arylamine N -Acetyltransferase Acetylates and Thus Inactivates para -Aminosalicylic Acid

Published:2016-12 Issue:12 Volume:60 Page:7505-7508
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wang Xude¹²,Yang Shanshan¹,Gu Jing¹,Deng Jiaoyu¹

Affiliation:

1. Key Laboratory of Agricultural and Environmental Microbiology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China

2. School of Stomatology and Medicine, Foshan University, Foshan, China

Abstract

ABSTRACT Mycobacterium tuberculosis arylamine N -acetyltransferase (TBNAT) is able to acetylate para -aminosalicylic acid (PAS) both in vitro and in vivo as determined by high-performance liquid chromatography (HPLC) and electrospray ionization-mass spectrometry (ESI-MS) techniques. The antituberculosis activity of the acetylated PAS is significantly reduced. As a result, overexpression of TBNAT in M. tuberculosis results in PAS resistance, as determined by MIC tests and drug exposure experiments. Taken together, our results suggest that TBNAT from M. tuberculosis is able to inactivate PAS by acetylating the compound.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01312-16

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