Superior Pyronaridine Single-Dose Pharmacodynamics Compared to Artesunate, Chloroquine, and Amodiaquine in a Murine Malaria Luciferase Model-Reference-Cited by-同舟云学术

Superior Pyronaridine Single-Dose Pharmacodynamics Compared to Artesunate, Chloroquine, and Amodiaquine in a Murine Malaria Luciferase Model

Published:2018-09 Issue:9 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Okoth Winter A.¹,Dukes Elijah J.²,Sullivan David J.¹

Affiliation:

1. W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

2. Baltimore Polytechnic Institute High School, Baltimore, Maryland, USA

Abstract

Many previous in vitro and in vivo preclinical malaria drug studies have relied on low-parasite-number drug inhibition numerically compared to the untreated controls. In contrast, human malaria drug studies measure the high-parasite-density killing near 100 million/ml.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00394-18

Reference28 articles.

1. Intramuscular Artesunate for Severe Malaria in African Children: A Multicenter Randomized Controlled Trial

2. Clinical Pharmacokinetics and Pharmacodynamics of Artemether-Lumefantrine

3. Pharmacokinetic and Pharmacodynamic Considerations in Antimalarial Dose Optimization

4. The chemotherapy of rodent malaria. XXII. The value of drug-resistant strains of P. berghei in screening for blood schizontocidal activity;Peters W;Ann Trop Med Parasitol,1975

5. Development of a pharmacodynamic model of murine malaria and antimalarial treatment with dihydroartemisinin

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