Intravenous Immunoglobulin Administration Significantly Increases BKPyV Genotype-Specific Neutralizing Antibody Titers in Kidney Transplant Recipients-Reference-Cited by-同舟云学术

Intravenous Immunoglobulin Administration Significantly Increases BKPyV Genotype-Specific Neutralizing Antibody Titers in Kidney Transplant Recipients

Published:2019-08 Issue:8 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Velay Aurélie¹²³,Solis Morgane¹²³,Benotmane Ilies²⁴³,Gantner Pierre¹²³,Soulier Eric¹²³,Moulin Bruno²⁴³,Caillard Sophie²⁴³,Fafi-Kremer Samira¹²³

Affiliation:

1. Virology Laboratory, Strasbourg University Hospital, Strasbourg, France

2. Strasbourg University, INSERM, IRM UMR-S 1109, Strasbourg, France

3. Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France

4. Nephrology Department, Strasbourg University Hospital, Strasbourg, France

Abstract

BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN) is one of the major causes of kidney graft dysfunction, and there are no BKPyV-specific antiviral therapies available. BKPyV neutralizing antibodies (NAbs) play key roles in protecting against BKPyV replication and represent a potential therapeutic or preventive strategy. In this study, we evaluated NAb titers in intravenous immunoglobulin (i.v. Ig) preparations and in kidney transplant recipients (KTR) before and after i.v.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00393-19

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