Azithromycin Protects against Zika Virus Infection by Upregulating Virus-Induced Type I and III Interferon Responses

Author:

Li Chunfeng1234,Zu Shulong56,Deng Yong-Qiang3,Li Dapei12,Parvatiyar Kislay7,Quanquin Natalie7,Shang Jingzhe12,Sun Nina56,Su Jiaqi68,Liu Zhenyang68,Wang Min68,Aliyari Saba R.7,Li Xiao-Feng3,Wu Aiping12,Ma Feng12,Shi Yi68,Nielsen-Saines Karin9,Jung Jae U.10ORCID,Qin Frank Xiao-Feng12,Qin Cheng-Feng3,Cheng Genhong7

Affiliation:

1. Center of Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

2. Suzhou Institute of Systems Medicine, Suzhou, Jiangsu, China

3. Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China

4. Institute for Immunity, Transplantation, and Infection, Stanford University, Stanford, California, USA

5. CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

6. University of Chinese Academy of Sciences, Beijing, China

7. Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California, USA

8. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

9. Division of Pediatric Infectious Diseases, Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, California, USA

10. Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA

Abstract

Azithromycin (AZM) is a widely used antibiotic, with additional antiviral and anti-inflammatory properties that remain poorly understood. Although Zika virus (ZIKV) poses a significant threat to global health, there are currently no vaccines or effective therapeutics against it. Here, we report that AZM effectively suppresses ZIKV infection in vitro by targeting a late stage in the viral life cycle.

Funder

National Science Foundation of China

NSFC Excellent Young Scientist

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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