Deletions of the Endocytic Components VPS28 and VPS32 in Candida albicans Lead to Echinocandin and Azole Hypersensitivity-Reference-Cited by-同舟云学术

Deletions of the Endocytic Components VPS28 and VPS32 in Candida albicans Lead to Echinocandin and Azole Hypersensitivity

Published:2006-10 Issue:10 Volume:50 Page:3492-3495
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cornet Muriel¹²,Gaillardin Claude¹,Richard Mathias L.¹

Affiliation:

1. Microbiologie et Génétique Moléculaire, Institut National Agronomique Paris-Grignon, Institut National de la Recherche Agronomique UMR1238, Centre National de la Recherche Scientifique UMR2585, 78850 Thiverval-Grignon, France

2. Microbiologie, Hôtel-Dieu, 1 Place du Parvis Notre-Dame, 75181 Paris Cedex 04, Assistance Publique-Hôpitaux de Paris, Université Paris V, Paris Descartes, Paris, France

Abstract

ABSTRACT Vps28p and Vps32p act in both the endocytic and the pH signaling pathways in yeasts and are required for Candida albicans virulence. Here, we show that deletions of VPS28 and VPS32 increase the susceptibility of C. albicans to cell wall disruption agents, echinocandin and azole antifungal agents.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00391-06

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