Homomeric interactions between transmembrane proteins of Moloney murine leukemia virus-Reference-Cited by-同舟云学术

Homomeric interactions between transmembrane proteins of Moloney murine leukemia virus

Published:1996-02 Issue:2 Volume:70 Page:1266-1270
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Li X¹,McDermott B¹,Yuan B¹,Goff S P¹

Affiliation:

1. Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

Abstract

We have studied homomeric interactions between transmembrane proteins (TM) of the Moloney murine leukemia virus envelope using the Saccharomyces cerevisiae two-hybrid system. TM interacts strongly with itself but not with various control proteins. Deletional and mutational analyses indicated that the putative leucine zipper motif in the extracellular domain of TM is essential and sufficient to mediate the binding. The first three repeats of the leucine zipper-like motif are the most important in mediating the interaction. The TM-TM interaction detected in this system may play a role in several stages of viral replication.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.70.2.1266-1270.1996

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