Transcriptional Profile of Haemophilus influenzae : Effects of Iron and Heme-Reference-Cited by-同舟云学术

Transcriptional Profile of Haemophilus influenzae : Effects of Iron and Heme

Published:2006-08 Issue:15 Volume:188 Page:5640-5645
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Whitby Paul W.¹,VanWagoner Timothy M.¹,Seale Thomas W.¹,Morton Daniel J.¹,Stull Terrence L.¹²

Affiliation:

1. Departments of Pediatrics

2. Microbiology/Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104

Abstract

ABSTRACT Haemophilus influenzae requires either heme or a porphyrin and iron source for growth. Microarray studies of H. influenzae strain Rd KW20 identified 162 iron/heme-regulated genes, representing ∼10% of the genome, with ≥1.5-fold changes in transcription in response to iron/heme availability in vitro. Eighty genes were preferentially expressed under iron/heme restriction; 82 genes were preferentially expressed under iron/heme-replete conditions.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00417-06

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