Role of porin proteins OmpF and OmpC in the permeation of beta-lactams-Reference-Cited by-同舟云学术

Role of porin proteins OmpF and OmpC in the permeation of beta-lactams

Published:1982-12 Issue:6 Volume:22 Page:942-948
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Jaffe A,Chabbert Y A,Semonin O

Abstract

Mutants of Escherichia coli K-12 lacking major outer membrane proteins were obtained by selecting for resistance to the beta-lactam cefoxitin. Three classes of resistant strains were found: mutants in ompB, a regulatory locus for proteins OmpF and OmpC; mutants in ompF; and one mutant in tpo. The OmpF and OmpC proteins facilitate penetration of beta-lactams through the outer membrane.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.22.6.942

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