In Vitro Evaluation of N -Formimidoyl Thienamycin (MK0787) Combined with Amikacin Against Gram-Negative Bacilli and Staphylococcus aureus

Author:

Enciso M. Díez1,Lindemann M. L. Mateos1,Altés A. Gutiérrez1

Affiliation:

1. Servicio de Microbiologia, Ciudad Sani taria de la Seguridad Social “La Paz,” Madrid, Spain

Abstract

The in vitro synergistic activity of N -formimidoyl thienamycin and amikacin was determined against gentamicin-resistant enterobacteriaceae, Pseudomonas aeruginosa , and Staphylococcus aureus. N -Formimidoyl thienamycin showed synergism with amikacin against 19 of the gentamicin-resistant strains, 14 of the 49 strains of S. aureus , and only 1 strain of the 46 P. aeruginosa isolates.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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