Structural Insights into the Mechanisms of Action of Functionally Distinct Classes of Chikungunya Virus Nonstructural Protein 1 Inhibitors-Reference-Cited by-同舟云学术

Structural Insights into the Mechanisms of Action of Functionally Distinct Classes of Chikungunya Virus Nonstructural Protein 1 Inhibitors

Published:2021-06-17 Issue:7 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kovacikova Kristina¹,Gorostiola González Marina²³,Jones Rhian⁴,Reguera Juan⁴,Gigante Alba⁵,Pérez-Pérez María-Jesús⁵,Pürstinger Gerhard⁶,Moesslacher Julia⁷,Langer Thierry⁸,Jeong Lak Shin⁹,Delang Leen¹⁰,Neyts Johan¹⁰,Snijder Eric J.¹^ORCID,van Westen Gerard J. P.²,van Hemert Martijn J.¹^ORCID

Affiliation:

1. Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands

2. Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands

3. Oncode Institute, Leiden, the Netherlands

4. Aix-Marseille Université, INSERM, CNRS, AFMB UMR 7257, Marseille, France

5. Instituto de Química Médica (IQM-CSIC), Madrid, Spain

6. Department of Pharmaceutical Chemistry, University of Innsbruck, Innsbruck, Austria

7. Department of Pharmacy, University of Innsbruck, Innsbruck, Austria

8. Department of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria

9. College of Pharmacy, Seoul National University, Seoul, South Korea

10. KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium

Abstract

Chikungunya virus (CHIKV) nonstructural protein 1 (nsP1) harbors the methyltransferase (MTase) and guanylyltransferase (GTase) activities needed for viral RNA capping and represents a promising antiviral drug target. We compared the antiviral efficacies of nsP1 inhibitors belonging to the MADTP, CHVB, and FHNA series (6′-fluoro-homoneplanocin A [FHNA], its 3′-keto form, and 6′-β-fluoro-homoaristeromycin).

Funder

Oncode

ATIP-Avenir

European Commission

Fondation Bettencourt Schueller

MEC | Agencia Estatal de Investigación

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02566-20