Efficacy of Neuraminidase Inhibitors against H5N6 Highly Pathogenic Avian Influenza Virus in a Nonhuman Primate Model-Reference-Cited by-同舟云学术

Efficacy of Neuraminidase Inhibitors against H5N6 Highly Pathogenic Avian Influenza Virus in a Nonhuman Primate Model

Published:2020-06-23 Issue:7 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Nguyen Cong Thanh¹^ORCID,Suzuki Saori¹,Itoh Yasushi¹,Ishigaki Hirohito¹,Nakayama Misako¹,Hayashi Kaori¹²,Matsuno Keita³⁴^ORCID,Okamatsu Masatoshi³,Sakoda Yoshihiro³⁴,Kida Hiroshi⁵,Ogasawara Kazumasa¹⁶

Affiliation:

1. Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan

2. Department of Gynecology, Shiga University of Medical Science, Otsu, Japan

3. Laboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan

4. Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo, Japan

5. Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan

6. Research Center for Animal Life Science, Shiga University of Medical Science, Otsu, Japan

Abstract

Attention has been paid to H5N6 highly pathogenic avian influenza virus (HPAIV) because of its heavy burden on the poultry industry and human mortality. Since an influenza A virus carrying N6 neuraminidase (NA) has never spread in humans, the potential for H5N6 HPAIV to cause disease in humans and the efficacy of antiviral drugs against the virus need to be urgently assessed. We used nonhuman primates to elucidate the pathogenesis of H5N6 HPAIV as well as to determine the efficacy of antiviral drugs against the virus.

Funder

Japan Agency for Medical Research and Development

Ministry of Education, Culture, Sports, Science and Technology

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02561-19

Reference41 articles.

1. OIE. 2018. OIE situation report for avian influenza. OIE, Paris, France.