Affiliation:
1. Departments of Medicine and Pathology, Indiana University Medical Center, Indianapolis, Indiana 46223
Abstract
In rats, cephalothin exerts a protective effect upon the nephrotoxicity of gentamicin. To examine the possibility that this effect is also observed with carbenicillin, we gave the following (milligrams per kilogram) to rats daily for 14 days: gentamicin alone, 60; gentamicin plus cephalothin, 100, 500, or 1,000; gentamicin plus carbenicillin, 50, 100, 250, 500, or 1,000. A 500-mg/kg dose of cephalothin afforded significant partial protection from gentamicin nephrotoxicity, as did a 100-mg/kg dose of carbenicillin. Increasing doses of either drug failed to increase protection. The data suggest that in rats not only does carbenicillin afford some protection from gentamicin nephrotoxicity, but also that it does so at a lower dose than cephalothin. These findings may in part explain the divergent observations regarding the nephrotoxicity of cephalothin-gentamicin combination therapy in rats and humans.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference18 articles.
1. Barza M. V. Pinn P. Tanguay and T. Murray. 1977. Comparative nephrotoxicity of newer cephalosporins and aminoglycosides alone and in combination in a rat model p. 964-966. In W. Siegenthaler and R. Luthy (ed.) Current chemotherapy vol. 2. American Society for Microbiology Washington D.C.
2. Brier G. L J. Wolny and J. W. Smith. 1975. Serum bioassay for antimicrobial agents p. 57-71. In Technical improvement service no. 21. American Society of Clinical Pathologists Chicago.
3. Effect of cephalothin on renal cortical concentrations of gentamicin in rats;Dellinger P.;Antimicrob. Agents Chemother.,1976
4. Protective effect of cephalothin against gentamicin-induced nephrotoxicity in rats;Dellinger P.;Antimicrob. Agents Chemother.,1976
5. Maintenance of renal function in salt loaded rats despite severe tubular necrosis induced by HgCl 2;Dibona G. F.;Nephron,1971
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