Biochemical Properties and Roles of DprA Protein in Bacterial Natural Transformation, Virulence, and Pilin Variation-Reference-Cited by-同舟云学术

Biochemical Properties and Roles of DprA Protein in Bacterial Natural Transformation, Virulence, and Pilin Variation

Published:2023-02-22 Issue:2 Volume:205 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Sharma Dhirendra Kumar¹²,Misra Hari S.²^ORCID,Bihani Subhash C.²³,Rajpurohit Yogendra S.¹²

Affiliation:

1. Molecular Biology Division, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India

2. Homi Bhabha National Institute (DAE-Deemed University), Mumbai, Maharashtra, India

3. Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India

Abstract

Natural transformation enables bacteria to acquire DNA from the environment and contributes to genetic diversity, DNA repair, and nutritional requirements. DNA processing protein A (DprA) receives incoming single-stranded DNA and assists RecA loading for homology-directed natural chromosomal transformation and DNA strand annealing during plasmid transformation.

Funder

DAE | Bhabha Atomic Research Centre

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.00465-22

Reference84 articles.

1. Bacterial gene transfer by natural genetic transformation in the environment

2. DNA uptake during bacterial transformation

3. Fine‐tuning cellular levels of DprA ensures transformant fitness in the human pathogenStreptococcus pneumoniae