Affiliation:
1. Department of Bacteriology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514
Abstract
Polymorphonuclear leukocytes (PMN) of the domestic chicken lack myeloperoxidase and, therefore, may be useful for studies of myeloperoxidase-independent antimicrobial mechanisms. Before such studies were undertaken, it was important to investigate the antimicrobial capacity of these cells against species of opportunistic pathogens that cause infection in humans with defective PMN function. In vitro, chicken PMN, like normal human PMN, readily phagocytized and killed
Staphylococcus albus.
They also killed
Serratia marcescens, Escherichia coli
, and
Candida albicans.
Cytochemical methods confirmed the absence of myeloperoxidase from chicken PMN.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
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