Increased Frequency of Circulating CCR5 + CD4 + T Cells in Human Immunodeficiency Virus Type 2 Infection-Reference-Cited by-同舟云学术

Increased Frequency of Circulating CCR5 + CD4 + T Cells in Human Immunodeficiency Virus Type 2 Infection

Published:2006-12-15 Issue:24 Volume:80 Page:12425-12429
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Soares Rui¹,Foxall Russell¹,Albuquerque Adriana¹,Cortesão Catarina¹,Garcia Miguel¹²,Victorino Rui M. M.¹³,Sousa Ana E.¹

Affiliation:

1. Unidade de Imunologia Clínica, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal

2. Instituto Superior de Ciências da Saúde Egas Moniz, Quinta da Granja, 2829-511 Monte da Caparica, Portugal; and

3. Medicina 2, Hospital de Santa Maria, Av. Prof. Egas Moniz, 1649-035 Lisbon, Portugal

Abstract

ABSTRACT CCR5 expression determines susceptibility to infection, cell tropism, and the rate of human immunodeficiency virus type 1 (HIV-1) disease progression. CCR5 is also considered the major HIV-2 coreceptor in vivo, in spite of broad coreceptor use in vitro. Here we report a significantly increased proportion of memory-effector CD4 T cells expressing CCR5 in HIV-2-infected patients correlating with CD4 depletion. Moreover, HIV-2 proviral DNA was essentially restricted to memory-effector CD4, suggesting that this is the main target for HIV-2. Similar levels of proviral DNA were found in the two infection categories. Thus, the reduced viremia and slow rate of CD4 decline that characterize HIV-2 infection seem to be unrelated to coreceptor availability.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01557-06

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